AVUE AvuePrep - EDTA Gel (15% w/w) with Carbamide Peroxide (10%w/w)

Chelating (calcium binding) agent react with minerlized component of tooth.
Removal of the smear layer which is produced during instrumentation.
For chemical and mechanical cleaning of the root canal.
Shaping of the root canal via using rotary or hand files.
To be used with sodium hypochlorite as carbamide peroxide helps to produce nascent oxygen molecules when used with sodium hypochlorite.

Avueprep is a water soluble Ethylenediaminetetraaceticacid (EDTA) gel for root canal cleaning

Avueprep works by reacting with the mineral components of the hard tissues of the tooth. The chelating agent Avueprep softens the tissues, decalcifying the canal walls. It facilitates the mechanical preparation of the root canal and further removal of the smear layer, which opens dentin tubules

EDTA is a polyaminocarboxylic acid and a colorless, water-soluble solid. It is widely used to dissolve lime scale. Its usefulness arises because of its role as a hexadentate ligand and chelating agent, i.e. its ability to sequester metal ions such as Ca2+ and Fe3+.

Indications of Avueprep EDTA with carbamide peroxide:

Chelating (calcium binding) agent react with minerlized component of tooth.

Removal of the smear layer which is produced during instrumentation.

For chemical and mechanical cleaning of the root canal.

Shaping of the root canal via using rotary or hand files.

To be used with sodium hypochlorite as carbamide peroxide helps to produce nascent oxygen molecules when used with sodium hypochlorite

Smear layer removal:

The use of 15% -17%EDTA resulted in the greatest concentration of calcium ions compared with other chelating agents. Avueprep/Avueprep+ were the most efficient solution for removal of smear layer.

Antimicrobial activity

The antibacterial activity of Avueprep is due to the chelation of cations from the outer membrane of bacteria.

Effects on Dentin microhardness:

it reduce the root dentine microhardness, whereby the greatest differences are to be found in dentine immediately adjacent to the root canal lumen. After 3 min, Avueprep produced a greater reduction in microhardness.

Positively affect adhesion of root canal sealer:

Treating dentine with a combination of NaOCl and  EDTA produced stronger adhesion of resin based sealer compared to NaOCl alone.

Avueprep is Biocompatible

It has been proven that even if EDTA is forced through the apical foramen into the periapical tissues, no periapical tissue damage could be detected after 14 months. Furthermore, that placement of EDTA for 28 days after pulpotomy produced no pulpal tissue necrosis. However, changes in macrophage activity can cause the inflammatory reaction to be more easily initiated, but reduced capacity of phagocytosis can result. Furthermore, EDTA improves plasma extravasation and mediator action. 

Can remove calcium hydroxide while using Avueprep

It has been revealed that using Avueprep or NaOCl alone as irrigants did not remove calcium hydroxide from the root canal, but combining these two irrigants with hand instrumentation improved the effectiveness of the removal.

Composition of Avueprep

EDTA Disodium Salt – 15% w/w
Carbamide Peroxide – 10% w/w
Lubricants and Excipients

Manufacturer: BLV Healthcare Pvt Ltd
Country of Origin: India

What is EDTA gel?
Answer: Avue Prep is a water-soluble Ethylenediaminetetraacetic acid gel for root canal cleaning that contains 15%w/w and carbamide peroxide 10% w/w used for chemical and mechanical cleansing of root canals. It is designed to remove inorganic material, such as dentin smear layer and mineralized deposits, from the root canal system to facilitate cleaning and shaping.

How long should EDTA material be left in the canal?
Answer: It works well in the canal, Once the tooth has been isolated and the canals have been identified, place the unit dose dispenser snugly onto the Avue Prep EDTA syringe to avoid leaks. After inserting the Avue Prep into the canal opening, use endodontic files to carefully navigate the canal, adding more EDTA in between files. After the canal has been shaped, use distilled water and sodium hypochlorite to flush the EDTA out of the canal. Use a disinfectant to complete the biomechanical preparation before obturation.

Can EDTA gel be used with other irrigants?
Answer: Yes, it is often used in combination with other irrigants such as sodium hypochlorite to remove the smear layer and enhance cleaning.

Are there any side effects or contradictions to using EDTA gel?
Answer: EDTA gel is generally a safe irrigant material; however improper application like etching can lead to damage to root canals, and some might experience allergic reactions.